Degenerative diseases are common in pets. These diseases occur when the tissue function declines, resulting in gradual failure of the organ. Degeneration can occur in any tissue. Skin degeneration is common in older pets, for example, and is commonly noted as thinning of the skin. More troublesome, are the degenerative changes that occur in the ligaments and supporting structures of the bones and joints. Lameness from degenerative disease are the most common causes of forelimb and hindlimb lameness in dogs. They include, Cruciate Ligament Disease in the rear leg and Biceps Tendonitis in the foreleg. Degeneration of the internal organs cause many illnesses related to the liver, kidney and endocrine glands; resulting in renal failure, liver failure and diabetes, among others. Neurologic degeneration can be the cause of senility and cognitive dysfunction disease. Stem cells contain growth factors at levels over 1000 times the normal amount. These growth factors can help stop these degenerative diseases and reverse them in some cases. Regeneration is the process of reversal of degeneration. Mesenchymal Stem Cells (MSC), Platelet Rich Plasma (PRP), Platelet Rich Plasma Lysate (PRP-L), Autologous Conditioned Serum (ACS) and Conditioned Media (CM) are all regenerative products that can cause regeneration of these tissues.