Keratoconjunctivitis Sicca (KCS) is a common condition of the eye that occurs when the tear glands stop producing enough tears to keep the eye wet, or in some cases, stop producing tears altogether. Also known as "Dry Eye Syndrome" or DES, this condition grows progressively worse, slowly robbing the animal of its eyesight entirely.


Symptoms can include excessive blinking, protrusion of the third eyelid, swollen blood vessels of the eye, cloudy or ulcerated eyes, and discharge.

Breed Specific

Although common in dogs, breeds genetically predisposed to KCS are the Affenpinscher, Bulldog, Cavalier King Charles Spaniel, Chihuahua, Chow Chow, Cocker Spaniel, Dachshund, Gordon Setter, Kerry Blue Terrier, Lhasa Apso, Miniature Schnauzer, Pekingese, Poodle, Pug, Sealyham Terrier, Shih Tzu, Standard Schnauzer, Toy Poodle, West Highland White Terriers and Yorkshire Terrier.

Common Treatment Protocol

Immunosuppressant and artificial tear medications are generally prescribed for KCS. Immunosuppressant drugs work by “interrupting” the immune system’s attack of the tear glands, but it does not completely stop the attack. Aside from not producing the most favorable results, the other downfall is that it also comes with unwanted side effects and the dog will need this medication for the remainder of their life.

Stem Cell Treatment

Stem cells halt the attack on the tear glands by "resetting" the immune system. This means that your dog can be treated once with stem cell injections into his tear glands and third eyelid, and be resolved of the issue for life.

Administration of stem cells into lacrimal gland.
Administration of stem cells into lacrimal gland. Needle placed into dorsal fornix and advanced into gland.
Preparation for second stem cell injection.
Preparation for second stem cell injection.
Injection into the accessory lacrimal gland of the third eyelid.
Injection into the accessory lacrimal gland of the third eyelid.

Boo's Transformation

Further Reading

More information can be found on this page written by Dr. Garner: Allogeneic Stem Cell Therapy for KCS

Or, you may be interested in the following article by Cognizant Communication Corporation.

PDF ICON Allogeneic Mesenchymal Stem Cell Transplantation in Dogs With Keratoconjunctivitis Sicca

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